Manifestations of immune responses to human insulin and its analogues (short and prolonged) do not differ, since the modification of amoxil insulin molecule does not affect its immunogenic regions.
Despite the relatively high frequency of detection of autoantibodies to insulin in DM1, the frequency of immune complications of insulin therapy in DM1 and DM2 is practically the same. If we study inflammatory reactions at the injection site of modern insulins with passion and daily, then in the first 2-4 weeks of treatment they can be noted in 1-2% of cases, which spontaneously disappear in 90% of Amoxicillin over the next 1-2 months, and in the rest 5% of patients - within 6-12 months. There are three types of local allergic reactions and a systemic reaction to insulin preparations, and the symptoms of allergy to new insulin preparations remain the same as before in animals:
It is observed very rarely; local delayed inflammatory reaction (tuberculin type): develops 8-12 hours after Amoxicillin administration with a peak after 24 hours. At the injection site, an inflammatory reaction occurs with clear boundaries and usually involving subcutaneous fat, painful and often accompanied by itching and pain. Histologically revealed perivascular accumulation of mononucleocytes; systemic allergy: in the next few minutes after insulin administration, urticaria, angioedema, anaphylaxis and other systemic reactions develop, which, as a rule, are accompanied by an immediate local reaction.
local immediate inflammatory with whealing: within the next 30 minutes after injection, an inflammatory reaction occurs at the injection site, which may be accompanied by pain, itching and blisters and disappears within an hour. This reaction may be accompanied by re-development of inflammation at the injection site (pain, erythema) with a peak after 12-24 hours (biphasic reaction); Arthus phenomenon (reaction to the accumulation of antigen-antibody complexes at the injection site): moderate inflammation at the injection site after 4-6 hours with a peak after 12 hours and is characterized by local damage to small vessels and neutrophilic infiltrate.
Although the differential diagnosis of an allergy to an insulin preparation from an allergy of another genesis is not difficult, since it has characteristic distinguishing features (specific symptoms). My analysis of allergic reactions to insulin preparations over more than 50 years of practice of insulin therapy showed that an immediate type of systemic allergic reaction to insulin (such as urticaria, etc.) does not occur without allergy manifestations at the injection site (itching, redness, blistering rashes etc.).
It develops no earlier than 1-2 weeks after the start of insulin therapy, when the content of amoxil antibodies to insulin (reagins) increases sufficiently in the blood, which are not blocked in some patients by friendly, but insufficient growth of amoxil and IgG antibodies.